Complex chemistry, made tangible.
From simple linear sequences to highly modified therapeutic candidates, at milligram, gram and multi-gram scale for feasibility, lead optimisation, pre-clinical and IND-enabling studies.
Capability that flexes with your program.
We cover the full range of modern peptide chemistry, choosing the right approach for each sequence: linear, cyclic, bicyclic and stapled peptides, including disulfide-rich and side-chain cyclised sequences.
The right instrument for every sequence.
Microwave synthesis
Biotage Alstra Initiator+ for fast, high-efficiency Fmoc SPPS of difficult and longer sequences.
Parallel synthesis
48-channel Biotage Syro II for high-throughput libraries and multiple sequences at once.
Chemical protein synthesis
Native chemical ligation and fragment condensation for small proteins of 100+ residues.
Built-in flexibility for optimising candidates.
The structural, amino acid and conjugation chemistry used to improve peptide drug candidates.
Amino acid & backbone
- D-amino acid incorporation
- N-methylation
- Beta- and gamma-amino acids
- Alpha-methyl amino acids
- Unnatural and non-canonical amino acids
- Pseudoprolines and dipeptide building blocks
Conjugation & labelling
- PEGylation
- Fatty acid conjugation
- Fluorescent and biotin labelling
- Click chemistry conjugation
- Phosphorylation and glycosylation
- Isotopic labelling
- Photocleavable and photoswitchable groups
Cyclisation
- Head-to-tail cyclisation
- Lactam bridges
- Disulfide bond formation
- Hydrocarbon stapling
- Thioether and triazole click chemistry
- Bicyclisation
More molecules, more learning.
Our Syro II parallel synthesiser rapidly produces diverse peptide collections for screening, SAR studies and hit-to-lead optimisation, from design to LC-MS-characterised compounds in days.
Parallel production
48 channels synthesise multiple unique sequences at the same time.
Design flexibility
Positional and alanine scanning, truncation, substitution, stapled, cyclic, split-and-mix, retro-inverso and focused analogue libraries.
Macrocyclic libraries
Head-to-tail, lactam and disulfide macrocycles for hit identification and lead optimisation.
Analytical support
UPLC-UV and UPLC-MS confirm identity and crude purity for every library member.
Full data packages
QC for every library member, delivered with complete data.
Quality you can verify
Peptide content, MS-MS sequencing and water content analysis available for every compound.
Beyond the sequence.
Impurity synthesis
Authenticated process and degradation impurities as reference standards for analytical development and method validation.
Labelled peptides
Isotopic and fluorescent labels for PK/PD and mechanistic studies.
Counter-ion exchange
TFA to acetate, chloride and other pharmaceutically acceptable counter-ions.
Discuss your molecule.
Send us your sequence and requirements, and we’ll recommend the right synthesis strategy.