Turn a promising sequence into a clear proposition.
We build the process understanding, analytical methods and documentation your peptide needs for regulatory filings and a smooth transition to GMP manufacturing.
Peptide impurity synthesis
Authenticated reference standards for impurities from synthesis, degradation or storage, fully characterised to support method development and regulatory documentation.
Process research & development
We identify and optimise critical process parameters, resins and reagents, work-up and purification to build robust, scalable routes with consistent quality.
Analytical method development
HPLC and UPLC methods, mass spectrometry, amino acid analysis, peptide content, MS-MS sequencing and physicochemical testing, designed with future validation in mind.
Analytical and purification capabilities.
Analytical
- Agilent 1290 UPLC systems with PDA, VWD and MS detection
- LC-MS with mass deconvolution and MS/MS sequencing
- High-resolution MS through the SMS Pharmaceuticals central lab in Gagillapur
- Amino acid composition and chiral analysis
- Peptide content, counter-ion content and water content (TGA)
- Certificates of analysis tailored to your requirements
Purification & finishing
- Biotage Selekt flash chromatography
- Preparative RP-HPLC, up to 150 mL/min
- Mass-directed preparative purification
- Controlled lyophilisation
- Counter-ion exchange to acetate, chloride, sodium and others
- Scalable Fmoc SPPS routes from research scale to multi-gram
Evidence for the next milestone.
- 01Clear reports
Development reports that explain what was done, what was learned and what comes next.
- 02Certificates of analysis
Characterisation data for every material we supply.
- 03Transfer-ready methods
Analytical methods and process descriptions ready for transfer to GMP manufacturing.
Develop with intent.
Build process understanding early and generate the documentation you need for the next milestone.